Dehydroepiandrosterone (DHEA)

Dehydroepiandrosterone is an endogenous steroid hormone and one of the most abundant circulating steroids in humans (primarily in its sulfated form, DHEA-S). It is produced mainly by the adrenal cortex, with smaller amounts made in the gonads and brain. DHEA is a metabolic precursor to both androgens and estrogens – it can be converted into testosterone, estradiol, and other sex hormones in peripheral tissues. Beyond serving as a prohormone, DHEA has intrinsic biological activity: it binds to several nuclear receptors (including androgen receptor weakly) and may interact with neurotransmitter receptors (earning it classification as a neurosteroid as well). Physiologically, DHEA/DHEA-S levels peak in early adulthood and then exhibit a well-documented age-related decline; this has prompted extensive research into DHEA supplementation as an “anti-aging” strategy. Some epidemiological studies linked higher DHEA-S levels to reduced incidence of cardiovascular disease, better immune function, and improved bone density. However, randomized trials of DHEA supplementation in older adults have shown mixed results – some indicating improved well-being, libido, or skin health, and others showing minimal or no benefit. DHEA is available OTC in the US and is used (often without prescription) for fatigue, menopause symptoms, adrenal insufficiency, and more. It is generally well-tolerated at low to moderate doses, but can cause hormonal side effects (acne, hair changes, etc.) due to conversion into androgens/estrogens. In summary, DHEA is a key adrenal steroid with broad but subtle effects, and ongoing research continues to evaluate its therapeutic potential in aging, depression, and metabolic disorders.

• CAS: 53-43-0
• Molar Mass: 288.40 g/mol
• Chemical Formula: C_19H_28O_2
• Storage: Store at room temperature, tightly closed. Protect from light and humidity.
• Purity: ≥ 99%
• Quantity: 20 g powder