ALTO-100 (NSI-189) – Powder

NSI-189 is an experimental neurogenic compound originally developed for major depressive disorder. It exhibits pleiotropic pharmacological properties including antidepressant, pro-cognitive (nootropic), synaptoplastic (synapse-forming), and neurotrophic (neuron-growing) activities in preclinical studies. Notably, its antidepressant effect does not rely on monoamine pathways (it is monoamine-independent) distinguishing it from typical antidepressants. In a stroke model, NSI-189 demonstrated remarkable neurorestorative effects: treated animals showed significant neurite outgrowth and increased dendritic marker (MAP2) immunoreactivity in the hippocampus (and to a lesser extent in the cortex) compared to controls. These histological changes indicate that NSI-189 stimulated brain remodeling and neuroplasticity after injury. Indeed, NSI-189 treatment was associated with improved functional recovery in stroke-induced deficits. Parallel in vitro studies suggest NSI-189’s benefits may involve upregulation of neurotrophic factors (like BDNF and SCF) and mitigation of cell death pathways. In summary, NSI-189 is a promising neurogenic agent that enhances neurogenesis and synaptic connectivity, with ongoing research evaluating its potential in depression, stroke rehabilitation, and other neurological conditions.

• CAS: 1270138-40-3
• Molar Mass: 366.50 g/mol
• Chemical Formula: C_22H_30N_4O
• Storage: Store at room temperature in a tightly sealed container, away from heat, light, and moisture.
• Purity: ≥ 99% (NMR)
• Quantity: 2 g powder