Huperzine A (Naturally Occurring Alkaloid)

Huperzine A is an acetylcholinesterase inhibitor and NMDA-receptor antagonist extracted from the club moss Huperzia serrata. As a reversible acetylcholinesterase inhibitor, it increases acetylcholine levels in the synapses, which has led to interest in Huperzine A as a potential cognitive enhancer and neuroprotective agent. It has been investigated for neurodegenerative diseases like Alzheimer’s disease – some studies showed improved memory and cognition in patients, though evidence remains inconclusive and insufficient for formal medical recommendation (as of 2013)
Huperzine A also crosses the blood-brain barrier and acts as an NMDA receptor antagonist, which may help reduce excitotoxic neuronal damage. Despite its promise, long-term safety data are limited. It is available as a dietary supplement purported to improve memory and mental function, but regulatory agencies have not approved it as a definitive therapy for any condition. Caution is advised due to its potent cholinergic activity. (Notably, the purity of Huperzine A extracts can vary; the product here is a 0.4% Huperzine A natural extract.)

• CAS: 102518-79-6
• Molar Mass: 242.32 g/mol
• Chemical Formula: C_15H_18N_2O (Huperzine A free base)
• Storage: Store at room temperature, tightly sealed, away from heat, light, and moisture.
• Solubility: Soluble in DMSO and dimethylformamide (DMF); slightly soluble in ethanol and water.
• Purity: 0.4% (Huperzine A content in plant extract)
• Quantity: 2 g powder (extract form)