Usmarapride Fluid
Original price was: €20.00.€15.00Current price is: €15.00.
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Description
The solution does not fully dissolve; the powder will crash out after a few hours depending on temperature. Refrigeration delays precipitation, keeping it stable for roughly an hour and maintaining a homogenous suspension that allows for sufficiently accurate dosing. Shaking the suspension well before use helps ensure even distribution of the material.
Concentration: 10 mg/mL
Volume: 50 mL
Purity: 95.6% (remaining 4.4% is confirmed water)
Why Usmarapride (5-HT4 Agonist)
Usmarapride is the strongest overall 5-HT4 agonist candidate based on CNS penetration, potency, and pharmacokinetics.
CNS Permeability:
Usmarapride: Cb/Cp = 3.8
Prucalopride: 0.5
PF-04995274: 0.7
PRX-03140: 1.6
Usmarapride shows far higher brain:plasma concentration ratio than earlier compounds.
Bioavailability (F%):
Usmarapride: 34%
PF-0499527: 5.4%
PRX-03140: 2%
It avoids the extremely low F% seen in previous molecules.
Potency:
More potent than RS-67333 in sAPPα secretion assays.
Higher 5-HT4 receptor occupancy at lower oral doses.
Half-Life:
13.2–18.8 hours in humans.
Suven Life Sciences Background:
Suven has led long-term CNS-targeted 5-HT4 agonist development, optimizing affinity, Emax, permeability (Cb/Cp), and overall PK.
Suven CNS Permeability Progression:
2012: Compound 2D / PF-04995274 — Cb/Cp 0.7
2015: Compound 5A — 0.31
2018: Compound 4O — 0.8
2021: Compound 12L / Usmarapride — 3.8
Additional information
| Weight | 0.06 kg |
|---|---|
| Country of Origin | Netherlands |
| hs_code | 2934990000 |
