Nicotinamide Riboside Chloride – Powder

Description

Nicotinamide Riboside (NR) chloride is a stable form of vitamin B3 that serves as a direct precursor to NAD^+ (nicotinamide adenine dinucleotide) in cells. Chemically, it is a pyridine-nucleoside consisting of nicotinamide (vitamin B3) coupled to ribose, present as a chloride salt. NR has gained significant attention for its role in boosting cellular NAD^+ levels, which decline with age. Supplementation with NR has been shown in animal models to enhance mitochondrial function and energy metabolism, improving outcomes in age-related metabolic decline. For instance, chronic NR administration in mice suppressed age-associated weight gain, improved insulin sensitivity, and increased physical activity, effectively making older mice metabolically resemble younger ones. By raising NAD^+, NR activates sirtuins and other NAD^+-dependent enzymes involved in DNA repair, inflammation control, and circadian regulation. Early human trials indicate NR is safe and can significantly elevate NAD^+ in blood, with preliminary signs of benefits in muscle and lipid metabolism. Nicotinamide riboside chloride is being widely explored as an anti-aging and neuroprotective supplement, though definitive clinical evidence of its efficacy in humans is still under investigation.

• CAS: 23111-00-4
• Molar Mass: 290.70 g/mol
• Chemical Formula: C_11H_15ClN_2O_5 (NR chloride)
• Storage: Store at room temperature, tightly closed, protected from moisture. NR is hygroscopic and should be kept desiccated; for long-term storage, refrigeration is recommended.
• Purity: ≥ 99%
• Quantity: 10 g powder